Molecular interplay between the upregulated levels of Sad1 and UNC84 Domain Containing 2 (SUN2) and gene expression in medulloblastoma cells.
Tecalco-Cruz, A. C., Macías-Silva, M., Sosa-Garrocho, M., Poot-Hernández, A. C., Peralta-Alvarez, C. A., Ramírez-Jarquín, J. O., Cortes-González, C. C., Figueroa-Rivera, L., & López-Camarillo, C. (2024). Molecular interplay between the upregulated levels of Sad1 and UNC84 Domain Containing 2 (SUN2) and gene expression in medulloblastoma cells. Molecular Biology Reports, 51(1). https://doi.org/10.1007/s11033-024-10078-7
SUN2 is a nuclear envelope protein associated with the nuclear lamina and with proteins linked to nuclear export, splicing, and nucleo-cytoskeleton communication. Studies of SUN2 in cancer have been limited but have suggested that it has tumor-suppressive activity in some carcinomas. Medulloblastoma is a pediatric tumor that develops in the cerebellum and is currently classified intofour molecular groups: WNT (Wingless), SHH (Sonic Hedgehog), 3, and 4. SUN2 expression profiles appear to be altered in brain cancer but have not been previously evaluated in medulloblastoma.